health
Scientists Develop Method That Extends Anti-Tumor Drug Action
MOSCOW – Scientists from Sechenov University in Russia have developed an innovative system by which anti-tumor drugs reach the brain through the nasal cavity using gellan gum, allowing the drug to remain in the nasal mucosa for longer, the university's press service reported.
TL;DR
- Scientists at Sechenov University have created an innovative intranasal drug delivery system using gellan gum.
- The system allows anti-tumor drugs to stay in the nasal mucosa for up to six hours.
- This method enables drugs to reach the brain directly, bypassing the blood-brain barrier.
- Ribavirin was used as an active ingredient in the study, showing anti-tumor effects, particularly against glioblastoma.
- Animal studies demonstrated higher drug concentration in the brain compared to blood, with the drug remaining in the nasal lining for 24 hours.
- Histological analysis of nasal mucosa showed no pathological changes after the experiment.