health
Russian scientists with an international team have developed a new drug against breast cancer
MOSCOW – Scientists from the South Ural State University (SUSU) have, as part of an international research team, developed and tested new platinum compounds that can successfully treat breast cancer.
TL;DR
- New platinum compounds developed by an international team show high efficacy and reduced toxicity for breast cancer treatment.
- The compound AV1, a platinum(IV) ionic complex, was twice as effective as conventional drugs in inhibiting malignant cell growth in tests.
- AV1 is stable in the bloodstream and activates directly within cancer cells, minimizing side effects.
- Studies on rats showed AV1 suppressed tumor growth and metastasis, while also restoring mitochondrial function and exhibiting antioxidant and anti-inflammatory properties.
- Long-term use of AV1 did not cause systemic toxicity, liver, kidney, or heart issues in tested animals.
- Quantum chemistry and computer modeling were used to predict the compound's behavior and safety.
- The research involved scientists from SUSU, Ruđer Bošković Institute, Sam Higginbotham University of Agriculture and Technology, and King Saud University.